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Neuroscience research : the official journal of the Japan Neuroscience Societyの検索結果

Rivaroxaban vs. Warfarin in Japanese Patients With Atrial Fibrillation : The J-ROCKET AF Study CiNiiでみる

著者名:
HORI Masatsugu  MATSUMOTO Masayasu  TANAHASHI Norio  MOMOMURA Shin-ichi  UCHIYAMA Shinichiro  GOTO Shinya  IZUMI Tohru  KORETSUNE Yukihiro  KAJIKAWA Mariko  KATO Masaharu  UEDA Hitoshi  IWAMOTO Kazuya  TAJIRI Masahiro  Kajikawa Mariko 

抄録:
Background: The global ROCKET AF study evaluated once-daily rivaroxaban vs. warfarin for stroke and systemic embolism prevention in patients with atrial fibrillation (AF). A separate trial, J-ROCKET AF, compared the safety of a Japan-specific rivaroxaban dose with warfarin administered according to Japanese guidelines in Japanese patients with AF. Methods and Results: J-ROCKET AF was a prospective, randomized, double-blind, phase III trial. Patients (n=1,280) with non-valvular AF at increased risk for stroke were randomized to receive 15mg once-daily rivaroxaban or warfarin dose-adjusted according to Japanese guidelines. The primary objective was to determine non-inferiority of rivaroxaban against warfarin for the principal safety outcome of major and non-major clinically relevant bleeding, in the on-treatment safety population. The primary efficacy endpoint was the composite of stroke and systemic embolism. Non-inferiority of rivaroxaban to warfarin was confirmed; the rate of the principal safety outcome was 18.04% per year in rivaroxaban-treated patients and 16.42% per year in warfarin-treated patients (hazard ratio [HR] 1.11; 95% confidence interval 0.87–1.42; P<0.001 [non-inferiority]). Intracranial hemorrhage rates were 0.8% with rivaroxaban and 1.6% with warfarin. There was a strong trend for a reduction in the rate of stroke/systemic embolism with rivaroxaban vs. warfarin (HR, 0.49; P=0.050). Conclusions: J-ROCKET AF demonstrated the safety of a Japan-specific rivaroxaban dose and supports bridging the global ROCKET AF results into Japanese clinical practice.  (Circ J 2012; 76: 2104–2111)

出版年月日:
2012-08-25 , 
巻:
76 , 
号:
9 , 
ページ:
2104-2111 , 
ISSN:
13469843

Myopathy and neurogenic muscular atrophy in unexpected cardiopulmonary arrest CiNiiでみる

著者名:
KAWASHIMA Hisashi  ISHII Chiako  YAMANAKA Gaku  IOI Hiroaki  NISHIMATA Shigeo  KASHIWAGI Yasuyo  TAKEKUMA Kouji  MIYAJIMA Tasuku  HOSHIKA Akinori  NISHINO Ichizo  NONAKA Ikuya 

抄録:

出版年月日:
2011-04-01 , 
巻:
53 , 
号:
2 , 
ページ:
159-161 , 
ISSN:
13288067

Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease CiNiiでみる

著者名:
UM Hyun-Sub  KANG Eun-Bum  KOO Jung-Hoon  KIM Hyun-Tae  Lee-Jin  KIM Eung-Joon  YANG Chun-Ho  AN Gil-Young  CHO In-Ho  CHO Joon-Yong 

抄録:

出版年月日:
2011-02-01 , 
巻:
69 , 
号:
2 , 
ページ:
161-173 , 
ISSN:
01680102

Functional evaluation of paraplegic monkeys (Macaca mulatta) over fourteen months post-lesion CiNiiでみる

著者名:
HERNANDEZ-LAIN Aurelio  PIEDRAS Maria Jose G. M.  CAVADA Carmen 

抄録:

出版年月日:
2011-02-01 , 
巻:
69 , 
号:
2 , 
ページ:
144-153 , 
ISSN:
01680102

Clinical care and evolution of paraplegic monkeys (Macaca mulatta) over fourteen months post-lesion CiNiiでみる

著者名:
PIEDRAS Maria Jose G. M.  HERNANDEZ-LAIN Aurelio  CAVADA Carmen 

抄録:

出版年月日:
2011-02-01 , 
巻:
69 , 
号:
2 , 
ページ:
135-143 , 
ISSN:
01680102

The role of the dorsolateral prefrontal cortex in deception when remembering neutral and emotional events CiNiiでみる

著者名:
ITO Ayahito  ABE Nobuhito  FUJII Toshikatsu  UENO Aya  KOSEKI Yuta  HASHIMOTO Ryusaku  MUGIKURA Shunji  TAKAHASHI Shoki  MORI Etsuro 

抄録:

出版年月日:
2011-02-01 , 
巻:
69 , 
号:
2 , 
ページ:
121-128 , 
ISSN:
01680102

GABAergic pathway in a rat model of chronic neuropathic pain : Modulation after intrathecal transplantation of a human neuronal cell line CiNiiでみる

著者名:
VAYSSE L.  SOL J. C.  LAZORTHES Y.  COURTADE-SAIDI M.  EATON M. J.  JOZAN S. 

抄録:

出版年月日:
2011-02-01 , 
巻:
69 , 
号:
2 , 
ページ:
111-120 , 
ISSN:
01680102

"Interneurons" in the olfactory bulb revisited CiNiiでみる

著者名:
KOSAKA Toshio  KOSAKA Katsuko 

抄録:
The main olfactory bulbs (MOBs) are now one of the most interesting parts of the brain in at least two points; the first station of the olfaction as an excellent model for understanding the neural mechanisms of sensory information processing and one of the most prominent sites whose interneurons are generated continuously in the postnatal and adult periods. Here we point out some new aspects of the MOB organization focusing on the following 4 issues: (1) there might be both axon-bearing and anaxonic periglomerular cells (PG cells), (2) most parvalbumin positive medium-sized neurons in the external plexiform layer as well as a few nitric oxide synthase positive PG cells and calretinin positive granule cells are anaxonic but display dendritic hot spots with characteristics of axon initial segments, (3) some of so-called " short-axon cells" project to the higher olfactory related regions and thus should be regarded as " nonprincipal projection neurons" and (4) tyrosine hydroxylase positive GABAergic (DA-GABAergic) juxtaglomerular neurons (JG neurons) are a particular type of JG neurons as a main source of the interglomerular connection, forming an intrabulbar association system.

出版年月日:
2011-02-01 , 
巻:
69 , 
号:
2 , 
ページ:
93-99 , 
ISSN:
01680102

Modulation of neurotransmitter receptors and synaptic differentiation by proteins containing complement-related domains CiNiiでみる

著者名:
NAKAYAMA Minoru  HAMA Chihiro 

抄録:

出版年月日:
2011-02-01 , 
巻:
69 , 
号:
2 , 
ページ:
87-92 , 
ISSN:
01680102

SPP1 expression in spinal motor neurons of the macaque monkey CiNiiでみる

著者名:
YAMAMOTO Tatsuya  HIGO Noriyuki  SATO Akira  NISHIMURA Yukio  OISHI Takao  MURATA Yumi  YOSHINO SAITO Kimika  ISA Tadashi  KOJIMA Toshio 

抄録:

出版年月日:
2011-01-01 , 
巻:
69 , 
号:
1 , 
ページ:
81-86 , 
ISSN:
01680102

fMRI of patients with social anxiety disorder during a social situation task CiNiiでみる

著者名:
NAKAO Tomohiro  SANEMATSU Hirokuni  YOSHIURA Takashi  TOGAO Osamu  MURAYAMA Keitaro  TOMITA Mayumi  MASUDA Yusuke  KANBA Shigenobu 

抄録:

出版年月日:
2011-01-01 , 
巻:
69 , 
号:
1 , 
ページ:
67-72 , 
ISSN:
01680102

Monitoring cortical hemodynamic changes after sumatriptan injection during migraine attack by near-infrared spectroscopy CiNiiでみる

著者名:
WATANABE Yuka  TANAKA Hideaki  DAN Ippeita  SAKURAI Kunihiko  KIMOTO Kazuhito  TAKASHIMA Ryotaro  HIRATA Koichi 

抄録:

出版年月日:
2011-01-01 , 
巻:
69 , 
号:
1 , 
ページ:
60-66 , 
ISSN:
01680102

Involvement of central amygdala NMDA receptor mechanism in morphine state-dependent memory retrieval CiNiiでみる

著者名:
ARDJMAND Abolfazl  REZAYOF Ameneh  ZARRINDAST Mohammad-Reza 

抄録:

出版年月日:
2011-01-01 , 
巻:
69 , 
号:
1 , 
ページ:
25-31 , 
ISSN:
01680102